Chloroquine for malaria is only used as prophylaxis and treatment of certain types of malaria found in a small number of malarial areas where chloroquine-resistance has not yet occurred. It is not used to prevent or treat Plasmodium falciparum malaria, as resistance to chloroquine in this strain of malaria is widespread. It is vital to seek professional advice before going to a malarial area as to which prophylaxis and treatment are most suitable for that country. If not treated correctly, it is a potentially fatal disease.

Malaria is a tropical disease endemic to specific areas in the world, which is carried by the Anopheles mosquito. There are four main species of malaria: Plasmodium falciparum, , P. ovale and P. malariae. Each of these has specific areas of occurrence and may differ slightly in their onset, symptoms and management. Falciparum is the most dangerous of these, and using chloroquine for malaria caused by this species is not recommended.

The symptoms of malaria can be relatively non-specific and resemble flu-like symptoms. Fever, headache, general body pains and chills may occur, often spiking in the evenings. A person who has been to a malaria area who experiences any signs of illness should be seen by a doctor immediately, who should be informed of the fact that they have recently visited a malaria endemic area. Falciparum malaria can develop rapidly into a life-threatening disease.

Malaria prophylaxis, or preventative medication, is recommended when traveling to a malaria area. The choice of which drug to use will be made by the prescribing doctor, taking into consideration whether there is chloroquine-resistance in the area, the clinical picture of the patient, other medications they may be on and conditions they may have. Malaria resistance patterns may change from year to year, so updated information should always be sought.

Chloroquine for malaria prophylaxis is used in very few places where P. falciparum is not endemic, due to spreading resistance. When used for prophylaxis, it is taken as a weekly dose starting at least a week before entering the area, for the whole time while there, and for four weeks after leaving the area. Chloroquine for malaria treatment is used to treat chloroquine-sensitive, non-falciparum malaria and is usually given as a three day course.

As with any medication, chloroquine for malaria prophylaxis or treatment may interact with other medications and cause adverse effects. These should all be discussed with the prescribing or treating doctor. It is essential that any signs or symptoms of illness during or after visiting a malaria area should be treated as a medical emergency.