@wesley91: There are commercial herbicides such as Brush-B-Gone and Roundup that can be effective in killing poison oak. However, it doesn’t always work because the root system will often come back.
In those cases, you can physically remove them.
Be sure to wear protective clothing including thick gloves, long sleeves and full length pants. Use pruning shears to cut the plant back and immediately put the trimmings into a heavy duty trash bag. Loosen the soil around the base of the plant with a shovel. Grab the plant by placing both of your hands as close to the roots as possible and pull it from the ground. Place that inside the garbage bag.
You need to cover the area where you pulled the poison oak up with mulch, tarps, or newspapers to smother any seedlings.