@literally45-- No, wiping will not help much, you might actually spread it more that way. If you're sweating, you can absorb the sweat with some tissues and throw them away immediately and wash your hands. But changing clothes, towels and bedding regularly is key.
You should definitely change into new undergarments every single day. If you're active and sweat a lot, change your undergarments right after activity.
I know it's hard to keep changing into clean clothes. But what you can do is hand wash your bra or shirt before you go to bed and wear it fresh the next morning. Just continue doing this while your treatment continues. As for bedding, it should be changed at least once a week but more often if you can. And don't forget to use a fresh towel each time you shower.