Coenzyme-A is an enzyme that is thought to be at the center of metabolic processes in the body. Supplements of coenzyme-A might help chronic fatigue syndrome sufferers, people who are dealing with high levels of stress as well as those who have coenzyme-A deficiencies. When choosing a coenzyme-A supplement, it is important to ensure that the dosage does not exceed the daily recommended amount, which is 1,000 milligrams per day.

An essential enzyme, coenzyme-A is thought to be the impetus that triggers other enzymes into action. It is believed to be a catalyst for chemical reactions in the body and is necessary for the successful conversion of nutrients — such as fat, carbohydrates and protein — into energy. Adequate coenzyme-A levels are needed for efficient fatty acid metabolism as well as for optimal absorption and utilization of coenzyme-Q10. Scientific studies indicate that coenzyme-A and coenzyme-Q10 work synergistically. Supplementation with both coenzyme-A and coenzyme-Q10 might be helpful in optimizing energy production in the body and lessening the symptoms of people who are suffering from chronic fatigue syndrome.

Coenzyme-A deficiency is not common, but it might lead to fatigue, generalized muscle aches and metabolic disorders. Supplementation can improve deficiency-induced symptoms. Coenzyme-A is necessary for the synthesis of the hormone melatonin, which plays a very important part in regulating the sleep cycle.

Intake of a coenzyme-A supplement can help lower high cholesterol. The enzyme also can be beneficial for athletes because it helps optimize energy conversion and energy use in the body. People who are under high levels of stress might also benefit from a coenzyme-A supplement.

Supplements of this essential enzyme typically are inexpensive and can be taken in pill or capsule form. Individuals who are on coenzyme-A supplementation will need to take the supplements every day to ensure maximum enzyme absorption and utilization. Coenzyme-A is a water-soluble compound, and supplements should be taken on an empty stomach. There have been very few documented side effects of coenzyme-A supplements, but high doses might cause diarrhea and nausea. Time-release capsules, which release the compound slowly over an extended period of time, might be preferable to quick-release supplements, especially for individuals who are prone to gastrointestinal upset.

Adequate vitamin B5 levels are needed for coenzyme-A synthesis in the body. It is possible for a coenzyme-A supplement to contain the enzyme’s precursor, vitamin B5, instead of coenzyme-A. Compounds that are rich in coenzyme-A generally are preferable to those that contain vitamin B5.